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Indications and Dosage
Oral
Hypertriglyceridaemia Adult: As a preparation containing 17% eicosapentaenoic acid and 11.5% docosahexaenoic acid: 5 g bid. As a preparation containing 46% eicosapentaenoic acid and 38% docosahexaenoic acid: 2-4 g daily. Oral Secondary prophylaxis of myocardial infarction Adult: As a preparation of omega-3 acid ethyl esters containing 46% eicosapentaenoic acid and 38% docosahexaenoic acid: 1 g daily.
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Administration
Should be taken with food.
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Special Precautions
Haemorrhagic disorders or those receiving anticoagulants or other drugs that have antithrombotic activity; asthmatic patients sensitive to aspirin. Monitor hepatic function in patients with hepatic impairment, especially if receiving high doses.
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Adverse Reactions
GI disturbances, including nausea, eructation, vomiting, abdominal distension, diarrhoea and constipation. Acne and eczema. Moderate increases in hepatic transaminases in patients with hypertriglyceridaemia.
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Action
Description:
Mechanism of Action: The omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid are long-chain n-3 polyunsaturated fatty acids, which compete with arachidonic acid for inclusion in cyclo-oxygenase and lipoxygenase pathways. Their actions include hypolipidaemic action (especially a reduction in plasma triglycerides) by reducing very-low-density lipoproteins; anti-inflammatory action, attributed to effects on leukotriene synthesis; and antiplatelet effect, attributed to effects on prostanoid synthesis, which promote vasodilatation, reduction in platelet aggregation, increased bleeding time and decreased platelet counts. |
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MIMS Class
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